Metabolic, Physiological and Behavioral Phenotyping Core

The Metabolic, Physiological and Behavioral Phenotyping Core (also referred to as the Animal Phenotyping Core) is directed by Dr. Nathan Qi and performs a variety of in vivo physiological assessments encompassing glucose homeostasis (glucose tolerance, insulin tolerance, hyperinsulinemic-euglycemic, hypo- or hyperglycemic clamps), lipid metabolism (3H-triolein lipid tolerance, 3H-palmitate FA fluxes) energy homeostasis (indirect calorimetry by CLAMS, Promethion systems with ambient temperature or dietary challenge), ultradian hormone secretion (Culex platform for serial biological fluid sampling from free moving, unrestrained mice), behavioral measurements (learning/memory, locomotor activity, anxiety, depression, meal pattern analysis, operant conditioning). 

Key aims of the core:

  • Provide investigators the essential resources for advanced, standardized phenotyping in mouse models of metabolic diseases caused by dietary, genetic, pharmacologic or other perturbations.
  • Aid MMPC investigators in the design, performance and interpretation of phenotyping assays conducted by the Core.

Please find our standard list of prices and services described in the table below. When you are ready to proceed, please follow the steps to submit a Request for Service.

Browse or Search for Services

Listed prices reflect internal UofM investigator rates, external customers are subject to additional fees, please inquire for a quote.

Test Number Test Name
MI 2000
Free study consultation and experimental design
Free
MI 2101
Insulin Sensitivity: OGTT or IPGTT + insulin measurement
$80.10 per mouse
$99.12 per rat
MI 2102
Insulin Sensitivity: OGTT or IPGTT w/o measuring insulin
$50.62 per mouse
$66.47 per rat
MI 2103
Insulin Sensitivity: Insulin Tolerance Test (ITT)
$44.27 per mouse
$50.62 per rat
MI 2104
Insulin Sensitivity: Hyperinsulinemic-euglycemic clamp (3H+14C)
$491.75 per mouse
$610.78 per rat
MI 2105
Insulin Sensitivity: Hyperglycemic Clamp (+ insulin $10/sample)
$422.64 per mouse
$478.57 per rat
+ insulin $10/sample
MI 2106
Insulin Sensitivity: Hypoglycemic Clamp
$422.64 per mouse
$478.57 per rat
MI 2107
Insulin Sensitivity: + Hepatic glycogen synthesis
$37.20 per animal
MI 2108
Insulin Sensitivity: + Hepatic de novo lipogenesis
$37.20 per animal
MI 2201
Energy Metabolism: Whole animal energy expenditure + free body composition
$39.69 per mouse/day
$40/d or $95/3d, or more days @$30/d
MI 2202
Energy Metabolism: Body temperature scan (pre-implanted T-chips)
$1.89 per mouse
MI 2203
Energy Metabolism: Methane production
$1.99 per mouse
MI 2204
Energy Metabolism: 13CO2 production
$1.99 per mouse
MI 2205
Energy Metabolism: Nonshivering thermogenesis without anesthesia
$55.08 per mouse
MI 2206
Energy Metabolism: Nonshivering thermogenesis with anesthesia
$65.67 per mouse
MI 2207
Energy Metabolism: Body composition
$11.83 per animal
MI 2208
Energy Metabolism: Organ or tissue composition
$3.86 per animal
MI 2209
Energy Metabolism: Body temperature (subq, BAT, or IP)
$1.79 per animal
MI 2210
Energy Metabolism: Bomb calorimetry (calorie content in food, feces, or tissue)
$34.39 per sample without sample collection
$60.55 per animal with sample collection (48hrs food intake & fecal production)
MI 2301
Lipid metabolism: Fat Tolerance Test (oral gavage with olive or corn oil)
$54.17 per animal
MI 2302
Lipid metabolism: Hepatic TG secretion (using Poloxamer 407)
$54.17 per animal
MI 2303
Lipid metabolism: Fat fluxes w/ 3H-triolene + 3 tissues
$140.60 per animal
MI 2401
Blood Sampling/Infusion/Injection: Automated blood sampling (including surgery)
$185.44 per mouse
$204.44 per rat
MI 2402
Blood Sampling/Infusion/Injection: Automated blood sampling+inject (including surgery)
$223.62 per sample
$243.80 per rat
MI 2403
Blood Sampling/Infusion/Injection: Steady state labeling (including surgery)
$223.27 per mouse
$243.53 per rat

Pages