The Metabolic, Physiological and Behavioral Phenotyping Core (also referred to as the Animal Phenotyping Core) is directed by Dr. Nathan Qi and performs a variety of in vivo physiological assessments encompassing glucose homeostasis (glucose tolerance, insulin tolerance, hyperinsulinemic-euglycemic, hypo- or hyperglycemic clamps), lipid metabolism (3H-triolein lipid tolerance, 3H-palmitate FA fluxes) energy homeostasis (indirect calorimetry by CLAMS, Promethion systems with ambient temperature or dietary challenge), ultradian hormone secretion (Culex platform for serial biological fluid sampling from free moving, unrestrained mice), behavioral measurements (learning/memory, locomotor activity, anxiety, depression, meal pattern analysis, operant conditioning).