Metabolism, Bariatric Surgery and Behavior Core

The Metabolism, Bariatric Surgery and Behavior Core (also referred to as the Animal Phenotyping Core) is directed by Dr. Malcolm LowDr. Nathan Qi and Dr. Randy Seeley and performs a variety of in vivo physiological assessments encompassing glucose homeostasis (glucose tolerance, insulin tolerance, hyperinsulinemic/euglycemic clamps), energy homeostasis (indirect calorimetry by CLAMS, dietary challenge), ultradian hormone secretion (Culex platform for serial biological fluid sampling from unrestrained mice), behavioral measurements (locomotor activity, meal pattern analysis, operant conditioning) and generation of bariatric surgery models. 

Key aims of the core:

  • Provide investigators the essential resources for advanced, standardized phenotyping in mouse models of metabolic diseases caused by dietary, genetic, pharmacologic or other perturbations.
  • Aid MMPC investigators in the design, performance and interpretation of phenotying assays conducted by the Core.

Please find our standard list of prices and services described in the table below. When you are ready to proceed, please follow the steps to submit a Request for Service.

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Listed prices reflect internal UofM investigator rates, external customers are subject to additional fees, please inquire for a quote.

Test Number Test Name
MI2029
Body Composition (Bruker Minispec LF 90II)
$14.60/per mouse
MI2030
Body Temperature (microchipping)
$16.20/per animal - subcutaneous (includes 10 measurements)
$21.60/per animal - intaperitoneal (includes 10 measurments)
$3.30/per each additional measurment
MI2031
Digestible Energy Content (Bomb Calorimeter)
$70.00/per mouse with fecal collection
$50.00/per mouse without fecal collection
MI2032
Fat Tolerance Test, Oral gavage (olive or corn oil)
$62.60/per mouse
MI2033
Fat Tolerance Test, Intravenous injection (20% Intralipid)
$189.80/per mouse
MI2034
Hepatic TG Secretion (Poloxamer 407 or Triton WR-1339)
$53.00/per mouse
MI2035
Free Fatty Acid (+ 3H-palmitate) Fluxes
$448.60/per mouse
MI2036
TG/FFA Cycling (3H-glycerol + 14C-palmitate + CLAMS)
$748.60/per mouse
MI2038
Automated Arterial Blood Sampling and/or Intravenous Infusion in undisturbed and unrestrained mice, Blood Sampling Only
$190.40/per mouse (includes surgery, 3-4 days acclamation, and one day blood sampling for up to 44 samples)
$37.50/per mouse for each additional day (up to 44 samples)
MI2039
Automated Arterial Blood Sampling and/or Intravenous Infusion in undisturbed and unrestrained mice, Intravenous Infusion only
$191.80/ per mouse (includes surgery, 3-4 days acclamation, and one day infusion for up to 24 hrs)
$21.30/ per mouse (for each additional day up to 44 samples)
MI2040
Automated Arterial Blood Sampling and/or Intravenous Infusion in undisturbed and unrestrained mice, Blood sampling AND intravenous infusion
$264.40/per animal, per day (includes surgery, 1-2 days acclamation, and one day blood sampling and infusion
$42.70/per anmial for each additional day
MI2041
Exercise Training
21.60/per mouse, per procedure
MI2042
Test of Running Capacity (run to exhaustion), WITHOUT measuring VO2 and VCO2
$37.30/per mouse, per procedure
MI2043
Test of Running Capacity (run to exhaustion), WITH measuring VO2 and VCO2 (VO2max)
$52.90/ per mouse, per procedure
MI2044
Running Wheel Activity (Med Associates)
$6.40/per mouse, per day
MI2046
Body Weight Recording
$6.60/per mouse, per procedure
MI2047
Manual Food or Water Recording
$6.60/ per mouse, per procedure
MI2048
Orogastric Gavage
$7.70/per mouse, per procedure
MI2049
Pair-Feeding
$6.60/per mouse, per procedure
MI2050
Rectal Temperature Recording (YSI 4600 precision thermometer)
$14.20/per mouse, per procedure
MI2052
24-hour Urine and/or Fecal Collection
$16.30/per mouse/day (metabolic cage)
$16.30/per mouse, per procedure (manual fecal collection in home cage)
MI2053
Tissue Dissection/Collection
$49.00/per mouse (up to 5 tissues except brain)
$10.90/per additional tissue
$16.40/per brain tissue (e.g. pituitary gland)
MI2054
Tail Vein Blood Sampling (plasma or serum)
$9.80/per mouse/procedure
$1.10/per sample for heparin plasma extraction (using heparin coated capillary tube) or
$2.10/per sample for EDTA plasma extraction (using EDTA coated micro tube)
$1.50/per sample to include blood glucose (glucose meter) or
$6.50/per sample to include plasma glucose (colorimetric kit)
$12.60/per sample to include plasma insulin (ELISA kit)
MI2055
Retro-orbital bleeding (under isoflurane anesthesia)
$16.40/per mouse/procedure
$1.10/per sample for heparin plasma extraction (using heparin coated capillary tube) or
$2.10/per sample for EDTA plasma extraction (using EDTA coated micro tube)
$1.50/per sample to include blood glucose (glucose meter) or
$6.50/per sample to include plasma glucose (colorimetric kit)
$12.60/per sample to include plasma insulin (ELISA kit)
MI2056
Tail Vein Injection
$8.80/per mouse/procedure

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