***The Phenotyping Core is now accepting experiments. However, some adjustments have been made in order to remain compliant with social distancing guidelines. Some experiments may take longer to complete so please contact core staff as soon as possible to schedule your study.
The Metabolism, Bariatric Surgery and Behavior Core (also referred to as the Animal Phenotyping Core) is directed by Dr. Malcolm Low and Dr. Nathan Qi and performs a variety of in vivo physiological assessments encompassing glucose homeostasis (glucose tolerance, insulin tolerance, hyperinsulinemic/euglycemic clamps), energy homeostasis (indirect calorimetry by CLAMS, dietary challenge), ultradian hormone secretion (Culex platform for serial biological fluid sampling from unrestrained mice), behavioral measurements (locomotor activity, meal pattern analysis, operant conditioning) and generation of bariatric surgery models.
Key aims of the core:
- Provide investigators the essential resources for advanced, standardized phenotyping in mouse models of metabolic diseases caused by dietary, genetic, pharmacologic or other perturbations.
- Aid MMPC investigators in the design, performance and interpretation of phenotying assays conducted by the Core.