Metabolic, Physiological and Behavioral Phenotyping Core

The Metabolic, Physiological and Behavioral Phenotyping Core (also referred to as the Animal Phenotyping Core) is directed by Dr. Nathan Qi and performs a variety of in vivo physiological assessments encompassing glucose homeostasis (glucose tolerance, insulin tolerance, hyperinsulinemic-euglycemic, hypo- or hyperglycemic clamps), lipid metabolism (3H-triolein lipid tolerance, 3H-palmitate FA fluxes) energy homeostasis (indirect calorimetry by CLAMS, Promethion systems with ambient temperature or dietary challenge), ultradian hormone secretion (Culex platform for serial biological fluid sampling from free moving, unrestrained mice), behavioral measurements (learning/memory, locomotor activity, anxiety, depression, meal pattern analysis, operant conditioning). 

Key aims of the core:

  • Provide investigators the essential resources for advanced, standardized phenotyping in mouse models of metabolic diseases caused by dietary, genetic, pharmacologic or other perturbations.
  • Aid MMPC investigators in the design, performance and interpretation of phenotyping assays conducted by the Core.

Please find our standard list of prices and services described in the table below. When you are ready to proceed, please follow the steps to submit a Request for Service.

Browse or Search for Services

Listed prices reflect internal UofM investigator rates, external customers are subject to additional fees, please inquire for a quote.

Test Number Test Name
MI2001
Catheterization of jugular vein
$74.45 per mouse
MI2002
Catheterization of carotid artery
$95.29 per mouse
MI2003
Catheterization of jugular vein AND carotid artery
$159.09 per mouse
MI2004
Catheterization of portal vein
$124.26 per mouse
MI2005
Catheterization of portal vein AND carotid artery
$189.45 per mouse
MI2006
Catheterization of stomach, bladder, intestine
$54.00 per mouse
MI2007
Partial pancreatectomy
$40.06 per mouse (60% removal)
$49.05 per mouse (90% removal)
MI2008
Parabiosis (a surgical union of two mice)
$131.10 per procedure
$96.56 per procedure (reverse surgery)
MI2009
Intracranial cannulation
$131.10 per mouse
MI2010
Renal capsule implantation
$51.36 per mouse
MI2011
Temperature chip or osmotic pump implantation
$12.25 per mouse
MI2012
Glucose Tolerance Test (OGTT or IPGTT)
$85.24 per mouse (including insulin measurement)
$47.82 per mouse (without insulin)
MI2013
Intravenous Glucose Tolerance Test (IVGTT)
$246.07 per mouse (including insulin measurement)
$183.05 per mouse (without insulin)
MI2014
Insulin Tolerance Test (ITT)
$41.98 per mouse
MI2015
Hyperinsulinemic-euglycemic clamp + 2 tracers (3H-glucose + 14C-2DG)
$481.90 per mouse
$650.72 per rat
MI2016
Hyperinsulinemic-euglycemic clamp + 1 tracer (3H-glucose OR 14C-2DG)
$424.16 per mouse
$548.45 per rat
MI2017
Hyperinsulinemic-euglycemic clamp w/o tracers
$388.73 per mouse
$440.79 per rat
MI2018
Hyperinsulinemic-euglycemic clamp using portal vein infusion
Please Inquire
MI2019
Plasma NEFA during clamp steady-state
$39.43 per mouse
MI2020
Hepatic de novo lipogenesis OR hepatic glycogen synthesis
$39.43 per animal
MI2021
Hyperglycemic Clamp
$388.73 per mouse
$440.79 per rat
Excluding plasma insulin ($12/sample)
MI2022
Hyperinsulinemic-hypoglycemic clamp
$388.73 per mouse
$440.79 per rat
MI2023
Whole body energy expenditure (including 1 free body composition)
$41.69 per animal/day (CLAMS)
$44.03 per mouse/day (Premetheon)
MI2024
Per temperature setting (thermoneutrality or cold) and temperature scan
$2.42 per mouse
$2.05 per scan (body temperature scan)
MI2025
Non-shivering thermogenesis using norepinephrine (including 24h acclimation at 30°C)
$52.30 per mouse (no anesthesia)
$64.63 per mouse (with pentobarbital, IP)

Pages