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About Us

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The Administrative Core, directed by Dr. Malcolm Low and Dr. Randy Seeleyprovides overall administrative leadership and scientific oversight of the Michigan Mouse Metabolic Phenotyping Center (MMMPC); promotimg the availability of MMPC resources to investigators at the University of Michigan, our regional partners (Michigan State University, Wayne State University and the University of Toledo) and other institutions nationally. The Admininstrative Core also establishes standardized documents, protocols and quality control procedures as well as facilitates research technology development and training resources for the Center’s four core laboratories.


Contact us at mighiganmmpc@med.umich.edu or 734-232-9706

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The Animal Care and Germ-Free Mouse Core, directed by, Dr. Robert SiglerDr. Jennifer Lofgren and Dr. Kathryn Eatonplays a central role in the management of animal flow through the Center’s phenotyping cores from initial acquisition to final disposition of imported mice. The gateway for all phenotyping involving live mice, the Animal Care and Germ-Free Mouse Core provides mouse importation, quarantine, housing, veterinary care, clinical chemistry and histopathology services; as well as, hosts a germ-free mouse facility that interacts with the Microbiome core to produce and distribute germ-free and gnotobiotic mouse models.

click HERE to place an order and learn more about the services the Animal Care and Germ Free Mouse Core offers as part of the Michigan Mouse Metabolic Phenotyping Center.

For questions regarding In-Vivo Animal services, contact us at ulam-ivac@umich.edu or call (734) 647-0731 for additional information, or to set up an appointment to consult with IVAC on your next research project. 

For questions regarding Germ-Free Mouse services contact us at ulam-germfree@umich.edu or (734) 615-9420 for additional information, or to set up an appointment to consult with our team on your next research project. 
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The Metabolism, Bariatric Surgery and Behavior Core (also referred to as the Animal Phenotyping Core), directed by Dr. Malcolm LowDr. Nathan Qi and Dr. Randy Seeley, performs a variety of in vivo physiological assessments encompassing glucose homeostasis (glucose tolerance, insulin tolerance, hyperinsulinemic/euglycemic clamps), energy homeostasis (indirect calorimetry by CLAMS, dietary challenge), ultradian hormone secretion (Culex platform for serial biological fluid sampling from unrestrained mice), behavioral measurements (locomotor activity, meal pattern analysis, operant conditioning) and generation of bariatric surgery models. 

Key aims of the core:
  • Provide investigators the essential resources for advanced, standardized phenotyping in mouse models of metabolic diseases caused by dietary, genetic, pharmacologic or other perturbations.
  • Aid MMPC investigators in the design, performance and interpretation of phenotying assays conducted by the Core.
click HERE to place an order and learn more about the services the Metabolism, Bariatric Surgery and Behavior Core offers as part of the Michgian Mouse Metabolic Phenotyping Center.

For questions, contact Nathan Qi at nathanqi@med.umich.edu or Melanie Schmitt at mlschmi@med.umich.edu for additional information, or to set up an appointment to consult with our team on your next research project. 

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The Microvascular Complications Core, directed by Dr. Eva Feldman, Dr. David Antonetti and Dr. Jeffrey Hodginprovides a complete range of microvascular phenotyping of murine models of diabetes, obesity and metabolic disease; including validated, reproducible and standardized phenotyping of the 3 major microvascular complications: diabetic polyneuropathy (DPN), nephropathy (DN) and retinopathy (DR). 

DPN advanced testing will include phenotyping of models exhibiting neuropathy such as measures of cell death and oxidative stress in dorsal root ganglion (DRG) and peripheral nerve. 

DN advanced phenotyping will include measures of podocyte number, precise morphometric analysis of glomerular expansion, glomerular volume and tubulointerstitial fibrosis, EM morphometry of podocyte foot processes, immunohistochemical analysis of podocyte specific proteins, and glomerular isolation. 

DR advanced testing will include measures of retinal vascular permeability, retinal cell death and non-lethal measures of retinal morphology using optical coherence tomography and visual function using optokinetic response.

click HERE to place an order and learn more about the services the Microvascular Complications Core offers as part of the Michgian Mouse Metabolic Phenotyping Center.  

For questions, please contact Coordinating Manager, Cheng-mao Lin, Ph.D. at 734-232-8220 or chengmao@med.umich.edu for additional information, or to set up an appointment to consult with our team on your next research project. 

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The Microbiome Core, Directed by Dr. Vincent Young, Dr. Patrick Schloss and Dr. Thomas Schmidt, serves the specific needs of investigators who are studying the role that complex microbial communities can play in shaping the overall metabolic state of their host; including, provide analytical tools to investigators to permit determination of the structure of the microbiome in mouse models of disease and assistance in the cultivation of microbes that will permit hypothesis testing in murine models including the germfree animals that are available in the Animal Care Core.

click HERE to place an order and learn more about the services the Microbiome Core offers as part of the Michgian Mouse Metabolic Phenotyping Center.

For questions, contact Michael Dority at midority@umich.edu or 734-764-3016 for additional information, or to set up an appointment to consult with our team on your next research project. 

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